Works jointly with MNova12
Use the tools “M-binding” of MNova for:
- Simultaneous upload and processing of 2D titration spectra.
- Automated peak tracking of stacked spectra.
- Automated generation of binding curves.
- Easy exporting of binding curves into AFFINImeter-NMR.
Access to complex binding models
A list of advanced stoichiometric binding models is available, so the user can fit binding curves of complex interactions. These models are formed of one or two equilibria for the description of 1:1 and 1:n interactions, binding heterogeneity (competing ligands or competing receptors), two-site receptor or ligand, auto-association, auto-association plus binding and auto-association induced by binding. Besides, tailored binding models can be prepared with the tool “Model Builder”.
Select binding curves built in MNova from the NMR titration experiment and perform a global fitting in AFFINImeter-NMR using the same binding model for all curves to get a common value of binding constant(s), which is calculated as a global parameter(s).
Find the best experimental condition to perform your experiments, even with complex interactions.
Check Local minima
Check how reliable your results are and detect over-parametrization of the analyses.
Get advantage of supercomputing
Our cloud version of the software uses supercomputing system to offer you a faster and more reliable analysis.