KinITC

An original tool to get the full thermodynamic (KD, ΔH) and kinetic (kon, koff) profiles of the formation of 1:1 and 1:n ligand-receptor complexes. The information is obtained directly from standard ITC experiments, in an experimental environment “label-free” and “in solution”.

 

Model Builder

This tool allows users to create original stoichiometric binding models through an easy-to-use and clean interface. These models can be applied to the analysis of a plethora of binding interactions of higher complexity, like those involving binding heterogeneity, auto-association induced by binding, cooperative effects or conformational changes, to mention few.

 

Global Analysis

Upload several isotherms to the same fitting project and perform a global fitting using the same (or different) binding model for each isotherm; define global parameters “linked” across two or more isotherms or even relate parameters using mathematical equations. This tool is incredibly useful to assess data quality and reproducibility, and indispensable for the robust analysis of complex interactions.

 

Simulate isotherms

Find the best experimental condition to perform your experiments, even with complex interactions.

Check Local minima

Check how reliable your results are and detect over-parametrization of the analyses.

Get advantage of supercomputing

Our cloud version of the software uses supercomputing system to offer you a faster and more reliable analysis.

 

Obtain Scientific reports

Get all you data, figures, tables and tables ready for publications and presentations.